CELLine
Disposable Bioreactor for Efficient Protein Expression

 


Applications

• Monoclonal antibody production in hybridomas
• Recombinant protein expression in transfected cells
• Virus production
• Continuous culture maintenance for long-term studies
• High-density cell culture

Easy operation

Due to its uncomplicated design working with the CELLine bioreactor is as simple as with any standard tissue culture flask. For a straightforward control of the growth process, microscopic observation of the cells is made possible by the transparent design of the CELLine classic bioreactor. The system operates independently of any complicated control technology and works without any pump systems or agitation devices. Easily and securely stackable, CELLine flasks occupy a minimum of space in any standard CO2 incubator.
A specific adaptation of the cell culture techniques or media composition is generally not necessary when starting to work with CELLine and both, serum-supplemented or serum free media are suitable.

Cost efficiency

CELLine has been designed to bring substantial cost savings to cell cultivation. Labour costs are considerably reduced, because fewer disposable flasks need to be handled compared to other culture techniques in order to produce milligram amounts of protein. Also the expenses for media supplements are significantly reduced, since the addition of serum or other synthetic additives can be limited to the cell compartment. Furthermore, the high production yield and quality obtained in the relatively small culture volume of CELLine contribute to reduce costs and labour time in the subsequent downstream processing steps of the product.