美国Altogen公司是细胞类型特异性，预优化转染试剂，转染试剂盒，生物分子细胞内转送的全球制造商。为了高效交付目标分子（siRNA的DNA，mRNA的）公司启用先进的试剂配方和预优化转染协议设计。美国Altogen生物系统公司开发的脂质体，纳米粒子和可生物降解的聚合物为基础的转染技术运用于组合化学，分子和细胞生物学。
转染到培养的细胞中引入的外源分子（蛋白质，DNA或RNA），是常用的基因功能，调节基因表达，生化映射，和蛋白质生产研究。科学家使用各种载体分子进入肿瘤细胞株，原代细胞的交付的目标分子（质粒DNA，mRNA表达的siRNA，小分子RNA，蛋白质）。没有任何一个的发送方法，可以适用于所有类型的细胞转染试剂，细胞的细胞毒性和转染效率显着变化，取决于试剂，协议，和细胞类型。美国Altogen生物系统公司提供预优化转染试剂盒和电缓冲区超过150细胞类型，组织有针对性的 体内 应用。
Altogen实验室提供符合GLP规范的CRO服务，临床前毒理学 （IND），转染服务， 异种移植的动物模型， 细胞存储，RNA干扰（RNAi）和基因沉默 （的A-to-Z的siRNA的服务：设计，合成，在体外在体内验证，组织靶向shRNA的克隆和稳定的RNAi的细胞株开发），酶联免疫吸附试验开发，微生物鉴定服务（细菌的ID），生物修复的产品和服务。Altogen定制服务包括 培养稳定的细胞系，生成稳定的癌细胞系和原代细胞可以是非常昂贵和费时的，Altogen的细胞培养科学家改造基因的稳定表达细胞株的选择或产生稳定的RNAi的细胞系。
Altogen Biosystems is a leading manufacturer of cell type-specific, pre-optimized transfection reagents, in vivo transfection kits, and electroporation products for intracellular delivery of biomolecules. Efficient delivery of target molecules (siRNA, DNA, mRNA) enabled by advanced reagent formulation and pre-optimized transfection protocol design. Altogen Biosystems develops liposome-, nanoparticle-, and biodegradable polymer-based transfection technologies by applying combinatorial chemistry, molecular and cell biology expertise.
Transfection is the introduction of exogenous molecules (protein, DNA or RNA) into cultured cells and is commonly used to study gene function, modulation of gene expression, biochemical mapping, and protein production. Scientists use various carrier molecules to enable delivery of target molecules (pDNA, mRNA, siRNA, microRNA, protein) into cancer cell lines and primary cells. Unfortunately, no single delivery method or transfection reagent can be applied to all types of cells. Cellular cytotoxicity and transfection efficiencies vary dramatically and depend on the reagent, protocol, and cell type used. Altogen Biosystems offers pre-optimized transfection kits and electroporation buffers for more than 150 cell types, and tissue-targeted in vivo applications. Orders can be placed online at the inpidual product webpage.
Altogen Labs offers GLP compliant CRO services, pre-clinical toxicology (IND), transfection services, xenograft animal models, cell banking, RNA interference (RNAi) and gene silencing services (A-to-Z siRNA services: design, synthesis, in vitro and in vivo validation, tissue targeting, shRNA cloning, and stable RNAi cell line development), ELISA assay development, microorganism identification services (bacteria ID), and bioremediation products and services. Altogen custom services include development of stable cell line in 28 days. Generating stable cancer cell lines and primary cells can be very expensive and time-consuming. Altogen’s cell culture scientists transform cell lines of choice to stably express gene of interest or produce stable RNAi cell line.
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