富士化学有限公司是一个的专业硅胶填料制造商，拥有70多年的历史，积累了丰富的经验。硅胶产品始终是其核心业务，在中国大陆拥有广泛的工业客户基础，以其优越的性价比，是国内天然药物和合成药等原料药生产商的首选填料之一。
 Fuji(富士)填料 CHROMATOREX HLC SILICA

CHROMATOREX  HLC SILICA

HLC-P: Amino acids, Peptides separation

HLC-A: Organic acids, Nucleic acids, Sugars separation

Introduction

Hydrophilic Interaction Chromatography (HILIC) is a technique dedicated to the separation of polar and/or ionic compounds. Opposite to revered-phase (RP) mode separation, HILIC uses polar stationary phases and high

organic solvents comparable to normal phase (NP) mode. The polar analytes can partition into and out of the adsorbed water layer of the surface and can undergo ionic cation exchange interaction with silanol groups. In sum this will

lead to an enhanced retention of polar compounds and results in high loading capacities of those. While in RP-mode retention increases as ACN% decrease; in HILIC- mode the retention strongly increases as ACN% increase. Thus,

the elution of polar compounds show complementary selectivity in HILIC- compared to the separation in RP-mode. Fuji Silysia Chemical Ltd. (FSC) has developed two new media for HILIC mode named “HLC” Silica (Patent

applied). Both HLC Silicas have bipolar functional groups, covalent bonded on the silica surface. “HLC-A” can be applied for separation and large scale purification of a brought range of hydrophilic compounds while “HLC-

P” is dedicated to the separations of amino acids and peptides.

HLC SILICA

FSC introduces two different bipolar structure types of HLC silica: “HLC-A” and “HLC-P”.

HLC-P: carboxyl chain with carbon amid bonding having a tertiary Amide.

HLC-A: di-carboxyl chain with two carbon amid bonding (tertiary and secondary Amides).