Specifications
CAS # : 73573-88-3
Molecular Formula : C23H34O5
Molecular Weight : 390.5
Source : Penicillium sp.
Appearance : White solid
Purity : >95% by HPLC
Long Term Storage : -20°C
Solubility : Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Application Notes
Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first 
reported in 1976. Mevastatin, the prototype of the statin class, is a potent competitive inhibitor of HMG-CoA 
reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by 
inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by 
blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase 
and may induce bone morphogenic protein-2 (BMP-2).