Specifications
CAS # : 38966-21-1
Molecular Formula : C20H34O4
Molecular Weight : 338.5
Source : Nigrospora oryzae
Appearance : White to off-white powder
Purity : >97% by HPLC
Long Term Storage : -20°C
Solubility : Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Application Notes
Aphidicolin is a tetracyclic diterpene antibiotic isolated from fungi, notably Cephalosporium, Nigrospora, Harziella
and Phoma. Aphidicolin has antibiotic, antiviral and antimitotic properties, blocking the cell cycle at early S-phase.
This property has been used to synchronise cell pision and is useful as a tool in cell differentiation research.
Aphidicolin is a reversible inhibitor of DNA replication by inhibiting selected DNA polymerases. Aphidicolin induces
apoptosis, prolongs the half-life of DNA methyltransferase, is active against Leishmania parasites and acts
synergistically with the antitumour agents, vincristine and doxorubicin.
